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. 4 Serial, PONTO SECULLUM 4 No Cd, PONTO SECULLUM 4 Free Full.. Ponto. .Short- and long-term actions of intrathecal morphine in an experimental model of chronic neuropathic pain.
Chronic pain, its treatments and its neural mechanisms are poorly understood. We studied the effect of intrathecal morphine on hyperalgesia and allodynia induced in one hindpaw by a chronic constriction injury of sciatic nerve in female rats. The intrathecal morphine doses were given on the 2nd and 16th days of nerve ligation. Intrathecal morphine inhibited the mechanical hyperalgesia and the allodynia in a dose-dependent way. The long-term (for 14 days) effect of intrathecal morphine on mechanical hyperalgesia and allodynia was studied. The intrathecal morphine reduced allodynia for more than 14 days. The time course of intrathecal morphine induced analgesia showed that the onset of analgesia was gradual and reached at the 3rd day of morphine administration. The time of maximum analgesia showed that analgesia reached by morphine was more pronounced in the beginning and it diminished with time. The lowest dose of intrathecal morphine at which analgesia was observed was 0.5 microg. The lowest dose of morphine required to reduce mechanical hyperalgesia was 1 microg. The minimum dose of morphine required to reduce hyperalgesia was 4.5 microg and that required for allodynia reduction was 24 microg. All those doses were given on the 2nd day of nerve ligation. The results of the present study showed that intrathecal morphine reduces hyperalgesia and

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