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GRADE 6-8. ANNA VICTORIA’S FIT BODY GUIDE. PDF. FAQs. Credits. Disclaimer. Legal Disclaimer. Subscriptions.. App provides fitness plans (PDF), recipes, daily. Platform to help people understand the “why” of making. 5.7k.[The regulation of the apoptosis of embryonal kidney cells by cell division].
The role of the cell cycle and the growth factors were studied in the regulation of the apoptosis of developing cells of the kidney cortex. Cell cycle was arrested in embryonic kidney cells on 6-10th day in the G1 phase in the presence of mitotic inhibitors. The reformation of cell cycle occurred only after the dissipation of the mitotic inhibitors of the G0 period of the cell growth. The mitotic inhibitors were shown to prevent proliferation of the cells in the G1 period. In the absence of the mitotic inhibitors the apoptosis of embryonic kidney cells was not observed. A detailed study has shown that caspase-3 and caspase-9 mediate apoptosis in embryonic kidney cells that could not be prevented by the caspase-2, -6, -7, -8, -9 inhibitors. The pro-apoptotic proteins were shown to interact with p53 in the apoptotic process of the embryonic kidney cells. The spontaneous apoptosis was absent in the p53 mutants. By pharmacological activation of the cell cycle in the G0 and G1 phase of the growth, the apoptosis of embryonic kidney cells was inhibited. It is concluded that the regulation of the apoptosis of embryonic kidney

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